NIH Rare Diseases

Lucey-Driscoll syndrome, a form of transient familial hyperbilirubinemia, is a rare metabolic disorder that leads to very high levels of bilirubin in a newborn's blood. Babies with this disorder may be born with severe jaundice (yellow skin), yellow eyes and lethargy. It occurs when the body does not properly break down (metabolize) a certain form of bilirubin. If untreated, this condition can cause seizures, neurologic problems (kernicterus) and even death. Treatment for Lucey-Driscoll syndrome includes phototherapy with blue light (to treat the high level of bilirubin in the blood) and an exchange transfusion is sometimes necessary. Different inheritance patterns have been reported and in some cases, it occurs in individuals with no family history of the condition. Last updated: 11/15/2010

MalaCards based summary

Hyperbilirubinemia, Transient Familial Neonatal, is also known as lucey-driscoll syndrome, and has symptoms including jaundice, cerebral palsy and kernicterus. An important gene associated with Hyperbilirubinemia, Transient Familial Neonatal is UGT1A1 (UDP Glucuronosyltransferase Family 1 Member A1). Affiliated tissues include skin, eye and breast.

UniProtKB/Swiss-Prot

Transient familial neonatal hyperbilirubinemia: A condition characterized by excessive concentration of bilirubin in the blood, which may lead to jaundice. Breast milk jaundice is a common problem in nursing infants.