OMIM

The ductus arteriosus is a vital in utero vascular connection between the aorta and pulmonary artery that allows right ventricular output to bypass the nonventilated fetal lungs. Postnatal closure of the ductus arteriosus is an important step in normal cardiopulmonary transition. Failure of ductal closure results in patent ductus arteriosus (PDA), which occurs in approximately 2 to 8 per 10,000 term infants and constitutes 5% to 7% of all congenital heart defects (summary by Hajj and Dagle, 2012). For a discussion of genetic heterogeneity of isolated PDA, see PDA1 (607411). (617039)

MalaCards based summary

Patent Ductus Arteriosus 3, is also known as pda3, and has symptoms including patent ductus arteriosus An important gene associated with Patent Ductus Arteriosus 3 is PRDM6 (PR/SET Domain 6). Affiliated tissues include lung, heart and placenta.

UniProtKB/Swiss-Prot

Patent ductus arteriosus 3: A congenital heart defect characterized by the persistent opening of fetal ductus arteriosus that fails to close after birth. Fetal ductus arteriosus connects the pulmonary artery to the descending aorta, allowing unoxygenated blood to bypass the lung and flow to the placenta. Normally, the ductus occludes shortly after birth.