OMIM

Glomerulopathy with fibronectin deposits (GFND) is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life. Pathologic examination shows enlarged glomeruli with mesangial and subendothelial fibrillary deposits that show strong immunoreactivity to fibronectin (FN1; 135600) (Castelletti et al., 2008). (137950)

MalaCards based summary

Glomerulopathy with Fibronectin Deposits 1, also known as glomerulopathy with giant fibrillar deposits, is related to glomerulopathy with fibronectin deposits 2, and has symptoms including hypertension, proteinuria and nephropathy. An important gene associated with Glomerulopathy with Fibronectin Deposits 1 is GFND1 (Glomerulopathy With Fibronectin Deposits 1). Affiliated tissues include kidney.